Innate Immune Regulation And Cancer Immunotherapy-..

Código: 1029939 Marca: Springer Publishing

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Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.

ISBN	9781489985903
Autor(a)	Wang, Rong-Fu
Editora	Springer Publishing
Ano de edição	2014
Páginas	478
Acabamento	Brochura
Dimensões	23,40 X 15,60