Statistical Monitoring Of Clinical Trials: A Unified Approach-..

Código: 1025082 Marca: Springer Publishing

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The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ("the B-value") - irrespective of the test statistic. Thus, this book offers statisticians an accessible, incremental approach to understanding Brownian motion as related to clinical trials. The main body of the chapters is accessible to anyone with knowledge of a standard mathematical statistics text. More mathematically advanced readers will find rigorous developments in appendices at the end of chapters. Reading the book will develop insight into not only monitoring, but power, survival analysis, safety, and other statistical issues germane to clinical trials.

ISBN	9781441921345
Autor(a)	Proschan, Michael A.
Editora	Springer Publishing
Ano de edição	2010
Páginas	268
Acabamento	Brochura
Dimensões	23,40 X 15,60